Applications for APEX-based genotyping

APEX technology is a flexible and affordable solution for genotyping of various genetic variants in numerous organisms. The optimal number of screened genetic variants is 25-750 on one microarray. Due to the flexible development procedure APEX microarrays can be easily modified. Genorama provides the full range of spotted slides, consumables and chemicals for APEX reactions.

  • Detection of various genetic variations
  • Optimal for screening 25 – 750 genetic variants on one APEX microarray
  • Established APEX microarrays can be easily updated with new genetic variations



 


Genorama offers a growing number of genetic testing APEX microarrays. All microarrays consist of panels of disease or gene related genetic variants selected in collaboration with leading scientists. The APEX arrays are being manufactured in ISO 9001:2000 quality control environment. Along with the APEX microarrays, Genorama provides optimized PCR primer sets, protocols, consumables and training.

Current list of available APEX-based genetic tests

  Genetic test
 Genetic variations
  Genes  List of Genes
 1 Thalassemia mutation panel  74 2
beta-globin gene, delta-globin gene
 2 Hereditary hearing loss mutation panel  198 6
Connexin 26, Connexin 30, Connexin 31, pendrin, mitochondrial DNA, prestin
 3 Cystic fibrosis mutation panel  254 1
CFTR
 4 Ashkenazi Jewish diseases mutation panel  77  22 HEX A, BLM, ASPA, SMPD1, IKBKAP, DYT1, MEFV,MCOLN1, FANCC, F11, G6PC, BCKHDB, GJB2, LDLR, DLD, GDE, SERPINA1, NEB, PCDH15, ABCC8, GBA, CFTR
 5 Stargardt disease, cone-rod dystrophy mutation panel  558  1 ABCA4
 6 Bardet Biedl mutation panel  312  14 BBS1, BBS2, BBS3, BBS4, BBS5, BBS6, BBS7, BBS8, BBS9, BBS10,BBS12, PHF6, ALMS1, GNAS1
 7 Corneal dystrophy mutation panel  339  13 COL8A2, TGFBI, VSX1, CHST6, KRT3, KRT12, GSN, TACSTD2, CYP4V2, SOD1, TCF8/ZEB1, SLC4A11, UBIAD1
8
Hereditary Breast and Ovarian Cancer mutation panel 91
6
BRCA1, BRCA2, CHEK2, RAD51, NBN, CASP8
 9 Congenital stationary night blindness mutation panel  126  9 RHO, PDE6B, GNAT1, CABP4, GRM6, SAG, NYX, CACNA1F, CACNA2D
 10 Vitelliform macular dystrophy mutation panel 138
1
BEST1
11
Autosomal dominant retinitis pigmentosa mutation panel
385
16
Ca4, FSCN2, IMPDH1, NRL, PRPF3, PRPF31, PRPF8, RDS, RHO, ROM1, RP1, RP9, CRX, TOPORS, PNR, KLHL7
12
Autosomal dominant optic atrophy mutation panel
118
1
OPA-1

As for further, more detailed questions regarding the APEX-based microarrays, please contact info@genorama.com